(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione
(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE
CAS: 110351-94-5
Molecular Formula: C13H13NO5
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione - Names and Identifiers
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione - Physico-chemical Properties
| Molecular Formula | C13H13NO5 |
| Molar Mass | 263.25 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Melting Point | 183-185℃ (decomposition) |
| Boling Point | 666.6±55.0 °C(Predicted) |
| pKa | 11.20±0.20(Predicted) |
| Storage Condition | 2-8°C |
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione - Risk and Safety
| Hazard Class | IRRITANT |
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.799 ml | 18.994 ml | 37.987 ml |
| 5 mM | 0.76 ml | 3.799 ml | 7.597 ml |
| 10 mM | 0.38 ml | 1.899 ml | 3.799 ml |
| 5 mM | 0.076 ml | 0.38 ml | 0.76 ml |
Last Update：2024-01-02 23:10:35
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione - Reference Information
| Use | (S)-4-ethyl-4-hydroxy-7, 8-dihydro-1h-pyran O[3,4-F] indolizin-3, 6,10(4H)-one is a key intermediate for the synthesis of irinotecan and camptothecin analogs. |
| research application | camptothecin is a pentacyclic alkaloid extracted from Camptotheca acuminata by Wall et al. As an anti-cancer chemical substance, the compound quickly attracted people's attention because of its strong inhibitory activity against leukemia and other malignant tumors in animal experiments. In the total synthesis of camptothecin,(S)-4-ethyl-4-hydroxy-7, 8-dihydro-1h-pyran O[3,4-F] indolizine-3, 6, the total synthesis of 10(4H)-ketone is the focus of research. |
Last Update：2024-04-10 22:30:50
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CAS: 110351-94-5
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CAS: 110351-94-5
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